The Dutch humanist Desiderius Erasmus (1466?–1536) admired Academic skepticism in his Praise of Folly(1511), which provoked opposition from Christians like Philipp Melanchthon (1487–1560). Gianfrancesco Pico della Mirandola's Examen Vanitatis (1520) drew from both Cicero and Sextus Empiricus. Omer Talon emphasized the Academics' philosophical freedom from dogmatism in his Academia of 1547, and Petrus Ramus praised their rhetoric and style in Ciceronianus of 1557. Giulio Castellani (1528–1586) defended Aristotelianism against Academic skepticism in Adversus Marci Tullii Ciceronis (1558), arguing that disagreement is not as widespread as the skeptics claimed. Johannes Rosa (1532–1571) brought out a substantial early commentary on the Academica in German in 1571, and Pedro de Valencia (1555–1620) refashioned Academic skepticism in his own Academica of 1596, published in Spain.
Publication of Sextus Empiricus's works in the 1560s replaced Cicero as the chief source of information about ancient skepticism. After that point most authors drew their inspiration from both sources, so it is hard to speak of purely Academic skeptics from then on. One exception is David Hume (1711–1776), sometimes called an Academic skeptic, among other reasons because a character in his Dialogues concerning Natural Religion (1779) takes the role of an Academic. There has also been scholarly debate about whether other individual early modern figures were Academic skeptics or Pyrrhonians, but in this period the two traditions were often run together and few, if any, authors made a clear distinction.