Occasional references to the ancient Pyrrhonists can be found throughout the late Roman and early medieval periods. The oldest extant Greek manuscript of Sextus dates from the tenth century, and manuscripts of Latin translations existed in medieval collections by the fourteenth century. More manuscripts came into Italy from Byzantium in the mid-fifteenth century, when the Florentine religious leader Girolamo Savonarola (1452–1498) used Sextus to combat pagan philosophy非キリスト教哲学., and the humanist scholar Pico della Mirandola drew on Sextus to fight other dogmatists. Knowledge of the materials eventually spread into France and other northern countries.
1562ラテン訳出版by Henri II Estienne (Stephanus)
モンテーニュ(Essays; 1580–1595)： ”Defense of Raymond Sebond” セクスタス援用
The printing press made for the most influential dissemination普及 of these texts. Published Latin translations by Henri II Estienne (Stephanus) (1562) and Gentian Hervet (1569) provided the stimulus for a widespread "skeptical crisis." Michel de Montaigne (1533–1592) was the most influential of the early European writers to draw on the writings of Sextus in his Essais (Essays; 1580–1595). In his longest essay, "Defense of Raymond Sebond," Montaigne retailed most of the skeptical tropes and all of the skeptical vocabulary from Sextus Empiricus. In this and other essays he demolished pretensions to human knowledge and argued both sides of nearly all issues. He was never pessimistic but showed people how to live a good life in spite of skepticism, which helps explain why his work was so popular.